SYSTEMATIC DESCRIPTION OF SUBCELLULAR LOCATION FOR INTEGRATION WITH PROTEOMICS DATABASES AND SYSTEMS BIOLOGY MODELING

Approaches for automatically analyzing subcellular location on a proteome-wide basis have been developed. This permits proteins to be grouped into subcellular location families that share a statistically-indistinguishable pattern. This in turn creates a need for methods to connect these automatically determined locations to existing information in literature and databases, and to communicate the nature of the pattern for each family. The building of generative models is proposed to meet this need and their utility for simulations of cell behavior is discussed.