Title :
The Cytotoxicity and OS-Mediated Toxicity of One Nanosize Titanium Dioxide
Author :
Xu, Yang ; Xiao Guo-qiang ; Xiang Xiao-ling ; Yang Xu
Author_Institution :
Lab. of Environ. Sci., Huazhong Normal Univ., Wuhan, China
Abstract :
One kind of nanosize titanium dioxide (nano-TiO2) was successfully made through anodization of titanium in this study, and its cytotoxicity and OS-mediated toxicity was detected by MTT, SOD and MDA assay in vitro and in vivo. The results showed that high does (0.8, 1.6 mg/mL) of this nano-TiO2 can cause cytotoxicity and OS-mediated toxicity, and reverse dose-rate effect happened in the low and medium does (0.1, 0.2, 0.4 mg/mL) in the OS-mediated toxicity detection.
Keywords :
anodisation; biohazards; cellular biophysics; chemical hazards; enzymes; nanotechnology; titanium compounds; toxicology; MDA assay; MTT assay; OS-mediated toxicity; SOD assay; TiO2; anodization; cytotoxicity; in vitro study; in vivo study; nanosize titanium dioxide; reverse dose-rate effect; toxicity detection; Biochemistry; Biological materials; Gas detectors; In vitro; In vivo; Manufacturing; Nanotubes; Organic compounds; Surface morphology; Titanium;
Conference_Titel :
Bioinformatics and Biomedical Engineering , 2009. ICBBE 2009. 3rd International Conference on
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2901-1
Electronic_ISBN :
978-1-4244-2902-8
DOI :
10.1109/ICBBE.2009.5163586
