A microfabricated preconcentrating device for exhaled breath analysis

Author

Li, M. ; Biswas, S. ; Nantz, M.H. ; Higashi, R.M. ; Fu, X.A.

Author_Institution

Univ. of Louisville, Louisville, KY, USA

fYear

2011

fDate

5-9 June 2011

Firstpage

1148

Lastpage

1151

Abstract

Breath analysis is a promising non-invasive method for health diagnosis. Several ketones and aldehydes in breath have been recognized as metabolic indicators of certain lung diseases. We report a fabricated microreactor with thousands of micropillars that have been engineered to selectively preconcentrate ultra-trace gaseous ketones and aldehydes of breath. The micropillar surfaces are functionalized with a quaternary ammonium aminooxy salt for capturing trace carbonyl VOCs by means of an oximation reaction. The reacted adducts are analyzed by Fourier transform-ion cyclotron resonance mass spectrometry (FT-ICR-MS). This method provides a quantitative analysis of ketones and aldehydes in breath.

Keywords

Fourier transform spectra; lung; mass spectra; microfabrication; microreactors; organic compounds; pneumodynamics; FT-ICR-MS; Fourier transform-ion cyclotron resonance mass spectrometry; aldehydes; carbonyl VOC; exhaled breath analysis; fabricated microreactor; health diagnosis; lung diseases; metabolic indicators; microfabricated preconcentrating device; micropillars; noninvasive method; oximation reaction; quantitative analysis; quaternary ammonium aminooxy salt; ultratrace gaseous ketones; Asynchronous transfer mode; Cancer; Fabrication; Helium; Lungs; Methanol; Surface treatment; Breath analysis; FT-ICR-MS; Ketones and aldehyde; Microreactor; Preconcentrator;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969255

Filename

5969255