Title :
Multi-well structure for cell culture on the chemical imaging sensor
Author :
Miyamoto, K. ; Wagner, T. ; Schöning, M.J. ; Yoshinobu, T.
Author_Institution :
Dept. of Electron. Eng., Tohoku Univ., Sendai, Japan
Abstract :
We proposed an application to monitor the cellular metabolism using the chemical imaging sensor. We fabricated multi-well structure made of agarose film on sensor surface. As a model of cellular metabolism, urease enzyme was filled in a well. pH change of the well was clearly observed from chemical images. It demonstrated the potential of the combination of the chemical imaging sensor and the multi-well structure.
Keywords :
bioMEMS; biochemistry; biosensors; cellular biophysics; electrochemical sensors; enzymes; molecular biophysics; pH; semiconductor devices; agarose film; cell culture multiwell structure; cellular metabolism model; cellular metabolism monitoring; chemical imaging sensor; pH change; sensor surface; urease enzyme; Biochemistry; Chemicals; Films; Imaging; Light sources; Photoconductivity; Semiconductor device measurement; Chemical imaging sensor; cellular metabolism; light-addressable potentiometric sensor and multi-well structure;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969264
