Title :
MEMS-based AC differential scanning calorimetry
Author :
Wang, B. ; Lin, Q.
Author_Institution :
Dept. of Mech. Eng., Columbia Univ., New York, NY, USA
Abstract :
We present a MEMS-based approach to AC differential scanning calorimetry (DSC) of biomolecules. Based on a MEMS device that integrates microfluidic handling with highly sensitive thermoelectric detection as well as on-chip AC heating and temperature sensing, we perform DSC measurements under temperature modulation. For the first time, this allows MEMS-based AC-DSC detection of liquid biological samples, demonstrated by the measurements of protein unfolding. This MEMS AC-DSC approach has potential applications to label-free characterization of biomolecules.
Keywords :
biosensors; differential scanning calorimetry; microfluidics; proteins; temperature sensors; DSC measurements; MEMS-based AC differential scanning calorimetry; biomolecules; highly sensitive thermoelectric detection; liquid biological samples; microfluidic handling; on-chip AC heating; protein unfolding; temperature modulation; temperature sensing; Calorimetry; Frequency modulation; Heating; Micromechanical devices; Temperature measurement; Temperature sensors; Biomolecular characterization; MEMS; differential scanning calorimetry; protein unfolding; temperature modulation;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969293
