Specific and label-free immunoglobulin G antibody detection using nano porous hydrogel photonic crystals

Photonic crystal (PC) based biosensors have been attracted more attention due to their advantages, such as sensitivity, real time monitoring and low-cost realization. Especially, label-free PC bioassay is more attractive than labeling detection, because time-consuming and expensive labeling step for the targets can be eliminated. Point-of-care testing is possible without fluorescent equipments and quantitative and kinetic measurement of molecule interaction is allowable. We propose a specific and label-free immunoglobulin G antibody detection method using a nanoporous hydrogel PC by observing the color change. This proposed sensor has great potential for next generation of bioassay platform for diagnosis of pathogens.