Title :
Optimizing inhalable nanoparticles
Author :
Ely, Leticia ; Lobenberg, Raimar ; Finlay, Warren H. ; Roa, Wilson H Y
Author_Institution :
Fac. of Pharmacy & Pharm. Sci., Alberta Univ., Edmonton, Alta., Canada
Abstract :
The aim of this study was to develop a new system of carrier particles and to optimize their Mass Median Aerodynamic Diameter (MMAD). We investigated different formulations and synthesized a new type of carrier particle, which releases nanoparticles actively. The active release mechanism of the nanoparticles from the carrier particles was achieved using sodium carbonate together with citric acid in a water solution. The MMAD of these formulations ranged from 2.8 to 3.60 μm. This study shows that it is possible to produce carrier particles loaded with nanoparticles with an appropriate MMAD to reach the deep area of the lungs.
Keywords :
drugs; lung; nanoparticles; nanotechnology; patient treatment; pneumodynamics; active release mechanism; carrier particles; citric acid; inhalable nanoparticles; lungs; mass median aerodynamic diameter; sodium carbonate; water solution; Lungs; Mechanical engineering; Nanoparticles; Oncology; Pharmaceuticals; Powders; Shape; Solids; Spraying; Temperature;
Conference_Titel :
MEMS, NANO and Smart Systems, 2005. Proceedings. 2005 International Conference on
Print_ISBN :
0-7695-2398-6
DOI :
10.1109/ICMENS.2005.96
