Title :
Delivery of an anti-cancer drug from a magnetically controlled MEMS device show cytotoxicity in PC3 and HUVEC cells
Author :
Pirmoradi, F.N. ; Jackson, J. ; Burt, H. ; Chiao, M.
Author_Institution :
Dept. of Mech. Eng., Univ. of British Columbia, Vancouver, BC, Canada
Abstract :
We have developed a magnetically controlled MEMS drug delivery device for on-demand release of defined quantities of an anti-cancer drug, docetaxel (DTX). A drug-loaded micro reservoir (Ø6mm×550μm) is sealed by a 40μm-thick elastic magnetic PDMS (polydimethylsiloxane) membrane with a laser-drilled aperture (~100×100μm2). Discharge of the drug solution and the release rates are controlled by an external magnetic field. Controlled and reproducible release rates of DTX have been achieved for 35 days. We report on the cytotoxicity of the released drug from the device (monitored as cell viability) and show that DTX maintains cytotoxic effects for two months.
Keywords :
bioMEMS; cancer; cellular biophysics; drug delivery systems; drugs; magnetomechanical effects; DTX; HUVEC cells; PC3 cells; anticancer drug delivery; cell viability; cytotoxicity; docetaxel; drug solution; drug-loaded micro reservoir; elastic magnetic PDMS; external magnetic field; laser-drilled aperture; magnetically controlled MEMS device; polydimethylsiloxane membrane; release rates; size 40 mum; Apertures; Drug delivery; Drugs; Magnetic devices; Magnetic fields; Micromechanical devices; Reservoirs; MEMS; active drug release; controlled drug delivery; docetaxel; magnetic actuation; on-demand;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969372
