Design of a reproducible murine femoral fracture device

Transgenic mouse models are commonly used to investigate bone healing and test new treatments before human trials. The objective of this project was to design and produce a fracture device to overcome previous limitations including a low reproducible transverse fracture rate, two user operation and poor consistency over time from spring use. This was accomplished by using an easily modifiable kinetic energy level, a novel Mouse Positioning System and an electromagnet assembly. The data collected from the validation experiment was used in the development of a constitutive relationship between kinetic energy and fracture type. This design may be useful to researchers as a more efficient solution for creating reproducible transverse fractures in mice.