Electrochemically-based dose measurement for closed-loop drug delivery applications

Author

Gutierrez, Christian A. ; Sheybani, Roya ; Meng, Ellis

Author_Institution

Dept. of Biomed. Eng., Univ. of Southern California, Los Angeles, CA, USA

fYear

2011

fDate

5-9 June 2011

Firstpage

2839

Lastpage

2842

Abstract

We present a method for accurate, real-time tracking of drug dose volume in reservoir-based drug pump systems using electrochemical impedance measurements. Detection of physiologically-relevant drug volumes (500 nL-64 μL) and on-the-fly flow rate variations (2.78-80 μL/min) from a MEMS drug delivery system were demonstrated. The sensor consists of two microelectrodes integrated within the drug reservoir. This method is attractive for its simplicity, sensitivity (0.2 Ω/nL), and wide drug compatibility. The capability of electronic, real-time dose measurement paves the way for fully-integrated closed-loop drug delivery systems.

Keywords

drug delivery systems; drugs; electric impedance measurement; electrochemical impedance spectroscopy; microelectrodes; closed-loop drug delivery applications; drug dose volume; electrochemical impedance measurements; electrochemically-based dose measurement; microelectrodes; real-time tracking; reservoir-based drug pump systems; Current measurement; Drug delivery; Drugs; Electrodes; Impedance; Impedance measurement; Reservoirs; Drug delivery; dose tracking; electrochemical impedance;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969396

Filename

5969396