DocumentCode :
2533152
Title :
Real-time kinetics measurements of protein induced conformational changes in DNA
Author :
Spuhler, Philipp S. ; Knezevic, Jelena ; Yalcin, Ayca ; Dröge, Peter ; Rant, Ulrich ; Ünlü, M. Selim
Author_Institution :
Biomed. Eng., Boston Univ., Boston, MA, USA
fYear :
2009
fDate :
4-8 Oct. 2009
Firstpage :
545
Lastpage :
546
Abstract :
We combine electrical orientation of surface bound dsDNA probes with an optical technique for kinetic measurement of protein-induced conformational changes in DNA. The effects of probe surface density and protein variation are investigated.
Keywords :
DNA; molecular biophysics; molecular configurations; proteins; DNA conformational change; electrical orientation; probe surface density; protein; realtime kinetics measurements; Band pass filters; Biomedical measurements; DNA; Electrodes; Fluorescence; Gold; Kinetic theory; Probes; Proteins; Sequences;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
LEOS Annual Meeting Conference Proceedings, 2009. LEOS '09. IEEE
Conference_Location :
Belek-Antalya
ISSN :
1092-8081
Print_ISBN :
978-1-4244-3680-4
Electronic_ISBN :
1092-8081
Type :
conf
DOI :
10.1109/LEOS.2009.5343144
Filename :
5343144
Link To Document :
https://search.ricest.ac.ir/dl/search/defaultta.aspx?DTC=49&DC=2533152
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