Title :
High-yield blood plasma separation by modulating inertial migration in a contraction-expansion array microchannel
Author :
Lee, M.G. ; Choi, S. ; Kim, H.-J. ; Lim, H.K. ; Kim, J.-H. ; Huh, N. ; Park, J.-K.
Author_Institution :
Dept. of Bio & Brain Eng., KAIST, Daejeon, South Korea
Abstract :
We report contraction-expansion array (CEA) microchannels for high-yield blood plasma separation utilizing differential inertial migration. An abrupt change of the cross-sectional area curves fluid streams and accelerates the flow velocity, which induces Dean flow. Utilizing the balance between inertial lift force and Dean drag force, we were able to separate blood plasma from human whole blood with a level of 62.2% yield. The CEA microfluidic device is easy to fabricate in a single layer fabrication process and expected to be useful for a simple blood plasma extraction on a chip with high-yield.
Keywords :
bioMEMS; biochemistry; blood; drag; haemodynamics; haemorheology; microchannel flow; microfabrication; CEA microfluidic device; Dean drag force; Dean flow; blood plasma extraction-on-a-chip; contraction-expansion array microchannel; cross-sectional area curves; flow velocity; fluid streams; high-yield blood plasma separation; inertial lift force; inertial migration; single layer fabrication process; Blood; Drag; Fluorescence; Force; Microchannel; Plasmas; Contraction-expansion array (CEA); Dean flow; Inertial microfluidics; Plasma separation;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969423