DocumentCode
2533891
Title
A platform for in situ real-time measurement of protein induced conformational changes of DNA
Author
Spuhler, Philipp S. ; Knezevic, Jelena ; Yalcin, Ayca ; Dröge, Peter ; Rant, Ulrich ; Ünlü, M. Selim
Author_Institution
Biomed. Eng., Boston Univ., Boston, MA, USA
fYear
2009
fDate
4-8 Oct. 2009
Firstpage
461
Lastpage
462
Abstract
A platform for in situ and real-time measurement of protein induced conformational changes in dsDNA is presented. We demonstrate protein induced bending upon sequence specific binding of integration host factor (IHF) to dsDNA probes.
Keywords
DNA; bioMEMS; biosensors; lab-on-a-chip; molecular biophysics; molecular configurations; proteins; bending; dsDNA; dsDNA probes; in situ real-time measurement; integration host factor; protein induced-conformational changes; sequence specific binding; Biomedical measurements; DNA; Electric variables measurement; Electrodes; Fluorescence; Gold; Probes; Proteins; Sequences; Throughput;
fLanguage
English
Publisher
ieee
Conference_Titel
LEOS Annual Meeting Conference Proceedings, 2009. LEOS '09. IEEE
Conference_Location
Belek-Antalya
ISSN
1092-8081
Print_ISBN
978-1-4244-3680-4
Electronic_ISBN
1092-8081
Type
conf
DOI
10.1109/LEOS.2009.5343182
Filename
5343182
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