High-efficiency blood separation utilizing spiral filtration microchannel with gradually varied width

Author

Ju, Y.R. ; Geng, Z.X. ; Zhang, L.Q. ; Wang, W. ; Li, Z.H.

Author_Institution

Nat. Key Lab. of Nano/Micro Fabrication Technol., Peking Univ., Beijing, China

fYear

2011

fDate

5-9 June 2011

Firstpage

298

Lastpage

301

Abstract

A hybrid microfluidic separation device that uses the crossflow and the centrifugation effect to separate human plasma from blood cells has been designed and fabricated. The chip mainly consists of the spiral microchannel, which is divided into inner and outer mcirochannels by micropillar arrays. The slits between the micropillars act as filter. Clogging and jamming in this filtration structure are efficiently alleviated. Remarkably, the width of the inner microchannel is gradually decreasing from inlet to outlet in order to increase separation efficiency. The performances of the separation device were investigated theoretically and experimentally. Due to high separation efficiency and compact structure, it is envisaged that this device can be integrated with other microfluidic device for point-of-care diagnostics in the near future.

Keywords

blood; filtration; microchannel flow; blood cells; centrifugation effect; clogging; crossflow; filter; filtration structure; high-efficiency blood separation; human plasma; jamming; microfluidic separation device; micropillar arrays; point-of-care diagnostics; spiral filtration microchannel; Blood; Cells (biology); Force; Microchannel; Microfluidics; Plasmas; Spirals; Centrifugation; Microfluidic; Plasma; Separation;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International

Conference_Location

Beijing

ISSN

Pending

Print_ISBN

978-1-4577-0157-3

Type

conf

DOI

10.1109/TRANSDUCERS.2011.5969447

Filename

5969447