DocumentCode
2534473
Title
A Transmural Gradient in Angiotensin II Concentration in the Canine Ventricle
Author
Kim, Jung-Ho ; Junyuan Gao ; Xiurong Sun ; Cohen, I.S. ; Mathias, R.T.
Author_Institution
State Univ. of New York-Stony Brook, Stony Brook
fYear
2007
fDate
10-11 March 2007
Firstpage
195
Lastpage
196
Abstract
Transmural differences in the heart have long been known and their importance in normal heart function emphasized. Angiotensin II is a potent effector that is regularly targeted in heart failure treatments. We used the whole-cell patch clamp to investigate the effects of angiotensin II on NaK-ATPase activity in the canine left ventricle and we show that transmural gradients in NaK-ATPase activity and contractile force are established by a corresponding gradient in angiotensin II concentration.
Keywords
biochemistry; bioelectric phenomena; cardiology; enzymes; molecular biophysics; NaK-ATPase activity; angiotensin II concentration; canine ventricle; contractile force; heart failure treatments; transmural gradient; whole-cell patch clamp; Clamps; Heart;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioengineering Conference, 2007. NEBC '07. IEEE 33rd Annual Northeast
Conference_Location
Long Island, NY
Print_ISBN
978-1-4244-1032-3
Type
conf
DOI
10.1109/NEBC.2007.4413345
Filename
4413345
Link To Document