Title :
A Transmural Gradient in Angiotensin II Concentration in the Canine Ventricle
Author :
Kim, Jung-Ho ; Junyuan Gao ; Xiurong Sun ; Cohen, I.S. ; Mathias, R.T.
Author_Institution :
State Univ. of New York-Stony Brook, Stony Brook
Abstract :
Transmural differences in the heart have long been known and their importance in normal heart function emphasized. Angiotensin II is a potent effector that is regularly targeted in heart failure treatments. We used the whole-cell patch clamp to investigate the effects of angiotensin II on NaK-ATPase activity in the canine left ventricle and we show that transmural gradients in NaK-ATPase activity and contractile force are established by a corresponding gradient in angiotensin II concentration.
Keywords :
biochemistry; bioelectric phenomena; cardiology; enzymes; molecular biophysics; NaK-ATPase activity; angiotensin II concentration; canine ventricle; contractile force; heart failure treatments; transmural gradient; whole-cell patch clamp; Clamps; Heart;
Conference_Titel :
Bioengineering Conference, 2007. NEBC '07. IEEE 33rd Annual Northeast
Conference_Location :
Long Island, NY
Print_ISBN :
978-1-4244-1032-3
DOI :
10.1109/NEBC.2007.4413345
