Platelet damage accumulation: In vitro and mathematical models

Author

Sheriff, J. ; Nobili, M. ; Morbiducci, J.U. ; Redaelli, A. ; Jesty, J. ; Bluestein, D.

Author_Institution

State Univ. of New York-Stony Brook, Stony Brook

fYear

2007

fDate

10-11 March 2007

Firstpage

199

Lastpage

200

Abstract

A phenomenological model for platelet cumulative damage was developed to express the platelet activation state (PAS) in response to a specific shear stress loading waveform. genetic algorithms (GAs) were used for model identification. The model was fine-tuned using parameters obtained in vitro by application of a shear stress loading waveform to a Hemodynamic Shearing Device (HSD). The PAS was measured temporally using a modified prothrombinase method. The proposed analytical model and PAS prediction agree well with and follow the same trend as the experimental results.

Keywords

cellular biophysics; enzymes; genetic algorithms; haemodynamics; physiological models; shear flow; genetic algorithms; hemodynamic shearing device; in vitro model; mathematical model; modified prothrombinase method; platelet activation state; platelet cumulative damage accumulation; shear stress loading waveform; Biological materials; Biomedical engineering; Biomedical materials; Biomedical measurements; Blood; Cardiology; In vitro; Mathematical model; Predictive models; Stress;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2007. NEBC '07. IEEE 33rd Annual Northeast

Conference_Location

Long Island, NY

Print_ISBN

978-1-4244-1033-0

Electronic_ISBN

978-1-4244-1033-0

Type

conf

DOI

10.1109/NEBC.2007.4413347

Filename

4413347