Title :
Rapid and repeated bolus drug delivery enabled by high efficiency electrochemical bellows actuators
Author :
Sheybani, R. ; Gensler, H. ; Meng, E.
Author_Institution :
Biomed. Microsyst. Lab., Univ. of Southern California, Los Angeles, CA, USA
Abstract :
For the first time, rapid and repeatable delivery of precise drug boluses (up to 40 15-second boluses of 19.12 ± 0.73 μL cocaine within 50 minutes) is achieved with a high efficiency MEMS electrolysis actuator. Gas bubble recombination parameters and drug viscosity were investigated. Nafion®-coated electrodes provided superior pumping performance (linearity and repeatability) compared to uncoated electrodes.
Keywords :
bioMEMS; biomedical electrodes; drug delivery systems; electrochemical devices; electrostatic actuators; microfluidics; Nafion coated electrodes; drug bolus delivery; drug viscosity; gas bubble recombination parameters; high efficiency MEMS electrolysis actuator; high efficiency electrochemical bellow actuators; pumping performance; rapid bolus drug delivery; repeated bolus drug delivery; Actuators; Bellows; Drugs; Electrochemical processes; Electrodes; Gases; Surface treatment; Bolus drug delivery; Nafion® polymer coating; drug pump; electrochemical actuators;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS), 2011 16th International
Conference_Location :
Beijing
Print_ISBN :
978-1-4577-0157-3
DOI :
10.1109/TRANSDUCERS.2011.5969616
