Functionalization of ceramic liposomal nanoparticles, cerasomes, with antibodies

Ceramic liposomal nanoparticles, cerasomes, are functionalized with antibodies on their surfaces that act as targeting ligands. This is achieved by using the siloxane network present on the cerasome surface as the foundation for chemical treatment processes previously developed for silicon surfaces. The bio-functionality and physical integrity of the cerasomes are characterized demonstrating successful immobilization of antibodies on the cerasome surface. The surface functionalization allows the cerasomes to deliver drugs to targeted cells expressing certain types of receptors with desired selectivity and specificity, which are not possible using standard liposomes.