DocumentCode :
2556758
Title :
A microwave microdosimetric study on blood cells: Estimation of cell membrane permittivity and parametric EM analysis
Author :
Merla, Caterina ; Liberti, Micaela ; Apollonio, Francesca ; Nervi, Clara ; Inzeo, Guglielmo D.
Author_Institution :
ICEMB, Sapienza Univ. of Rome, Rome, Italy
fYear :
2009
fDate :
7-12 June 2009
Firstpage :
1333
Lastpage :
1336
Abstract :
In the study of the interaction of RF and MW fields with biological systems particular attention has been recently devoted to microdosimetric research. In this paper a microdosimetric study on erythrocytes is proposed. Facing this topic, two fundamental steps are needed: the set up of a proper membrane dielectric model valid up to the RF and MW range, and the set up of an appropriate EM solution on the cell environment. Concerning the first point, an accurate estimation of the membrane dielectric model and of its uncertainty has been performed, from permittivity measurements of erythrocytes solutions. Focusing on the second point, a quasi-static EM analysis solving the Laplace equation has been chosen. An analytical approach has been applied on simplified spherical cell geometry, while a numerical solver has been used for erythrocyte shaped cell. In this context the fundamental role of the dielectric membrane modeling on results reliability has been highlighted.
Keywords :
Laplace equations; bioelectric phenomena; biomembranes; cellular biophysics; dosimetry; permittivity; Laplace equation; cell membrane; erythrocytes; membrane dielectric model; microwave microdosimetry; parametric EM analysis; permittivity; quasistatic EM analysis; Biological system modeling; Biological systems; Biomembranes; Blood; Cells (biology); Dielectrics; Laplace equations; Performance evaluation; Permittivity measurement; Radio frequency; dielectric model; erythrocyte; microdosimetry; quasi static solution;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Microwave Symposium Digest, 2009. MTT '09. IEEE MTT-S International
Conference_Location :
Boston, MA
ISSN :
0149-645X
Print_ISBN :
978-1-4244-2803-8
Electronic_ISBN :
0149-645X
Type :
conf
DOI :
10.1109/MWSYM.2009.5165951
Filename :
5165951
Link To Document :
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