Fabrication and in vitro testing of porous silicon microcarriers

Author

Bragaru, A. ; Kusko, M. ; Simion, M. ; Iordanescu, A. ; Pascu, R. ; Danila, B.M. ; Craciunoiu, F. ; Diaconu, M.

Author_Institution

IMT Bucharest, Bucharest, Romania

Volume

1

fYear

2011

fDate

17-19 Oct. 2011

Firstpage

117

Lastpage

120

Abstract

Porous materials have been used over a decade in tissue engineering and drug delivery. The aim of this study was to prepare porous silicon microparticles with suitable dimensions for using as drug microcarriers. Two types of anticancer drugs, dacarbazine and bleomycine, have been loaded into these systems for in vitro drug release tests carried out by high pressure liquid chromatography (HPLC) method.

Keywords

biochemistry; biomedical materials; cancer; chromatography; drug delivery systems; drugs; microfabrication; molecular biophysics; organic compounds; porous materials; silicon; tissue engineering; HPLC method; Si; anticancer drugs; bleomycine; dacarbazine; drug delivery; drug microcarriers; drug release tests; high pressure liquid chromatography; microfabrication; porous materials; porous silicon microcarriers; tissue engineering; Drug delivery; Drugs; In vitro; Iron; Loading; Magnetic resonance imaging; Silicon; PS microcarriers; SPION; therapeutical agents;

fLanguage

English

Publisher

ieee

Conference_Titel

Semiconductor Conference (CAS), 2011 International

Conference_Location

Sinaia

ISSN

1545-827X

Print_ISBN

978-1-61284-173-1

Type

conf

DOI

10.1109/SMICND.2011.6095730

Filename

6095730