Evaluation of time of flight (TOF) and point spread function (PSF) reconstructions in the quantification of myocardial blood flow with 13N ammonia and PET: Comparison among reconstructions (reprojection, OSEM), software (PMOD and CARIMAS) and operators

Author

Presotto, Luca ; Busnardo, E. ; Bettinardi, V. ; Landoni, C. ; Todeschini, P. ; Rimoldi, O. ; Gilardi, M.C. ; Gianolli, L.

Author_Institution

Dept. of Phys., Milano-Bicocca Univ., Milan, Italy

fYear

2012

fDate

Oct. 27 2012-Nov. 3 2012

Firstpage

3979

Lastpage

3982

Abstract

Myocardial blood flow quantification with PET and 13NH3 is a well established technique to evaluate the coronary flow reserve in patient with different cardiomyopathies. We performed an in depth evaluation of the variation in the results when modifying the reconstruction technique (OSEM algorithms, analytical algorithms, OSEM algorithms including time of flight and point spread function modelling), when using different two different software implementing the same kinetic model (PMOD and CARIMAS) and we also evaluated the inter-operator variabilities with 2 operators.

Keywords

cardiology; haemodynamics; haemorheology; image reconstruction; medical image processing; optical transfer function; positron emission tomography; time of flight spectra; CARIMAS software; OSEM algorithms; PMOD software; PSF reconstruction; ammonia; analytical algorithms; cardiomyopathies; inter-operator variability; myocardial blood flow quantification; point spread function modelling; time of flight evaluation;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2012 IEEE

Conference_Location

Anaheim, CA

ISSN

1082-3654

Print_ISBN

978-1-4673-2028-3

Type

conf

DOI

10.1109/NSSMIC.2012.6551912

Filename

6551912