A Bionics Chemical Synapse

Author

Thanapitak, Surachoke ; Toumazou, Christofer

Author_Institution

Electr. & Electron. Eng., Imperial Coll. London, London, UK

Volume

7

Issue

3

fYear

2013

fDate

Jun-13

Firstpage

296

Lastpage

306

Abstract

Implementation of the current mode CMOS circuit for chemical synapses (AMPA and NMDA receptors) with dynamic change of glutamate as the neurotransmitter input is presented in this paper. Additionally, circuit realisation for receptor GABA_A and GABA_B with an electrical signal which symbolises γ -Aminobutyric Acid (GABA) perturbation is introduced. The chemical sensor for glutamate sensing is the modified ISFET with enzyme (glutamate oxidase) immobilisation. The measured results from these biomimetics chemical synapse circuits closely match with the simulation result from the mathematical model. The total power consumption of the whole chip (four chemical synapse circuits and all auxiliary circuits) is 168.3 μW. The total chip area is 3 mm² in 0.35-μm AMS CMOS technology.

Keywords

CMOS integrated circuits; biochemistry; bioelectric phenomena; biomedical electronics; biomimetics; biosensors; chemical sensors; enzymes; ion sensitive field effect transistors; mixed analogue-digital integrated circuits; molecular biophysics; neurophysiology; γ -Aminobutyric Acid perturbation; AMPA receptors; AMS CMOS technology; GABA_A receptor; GABA_B receptor; NMDA receptors; auxiliary circuits; biomimetics chemical synapse circuits; bionics chemical synapse; chemical sensor; circuit realisation; current mode CMOS circuit; electrical signal; enzyme immobilisation; glutamate oxidase immobilisation; glutamate sensing; mathematical model; modified ISFET; neurotransmitter input; power 168.3 muW; size 0.35 mum; total chip area; total power consumption; CMOS integrated circuits; Chemicals; Integrated circuit modeling; Mathematical model; Neurons; Neurotransmitters; Transconductance; Bio-inspired circuit; chemical synapse; glutamate ISFET; Action Potentials; Amino Acid Oxidoreductases; Bionics; Computer Simulation; Electric Power Supplies; Electronics, Medical; Enzymes, Immobilized; Equipment Design; Glutamic Acid; Humans; Iontophoresis; Kinetics; Models, Theoretical; N-Methylaspartate; Synapses; Synaptic Transmission; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; gamma-Aminobutyric Acid;

fLanguage

English

Journal_Title

Biomedical Circuits and Systems, IEEE Transactions on

Publisher

ieee

ISSN

1932-4545

Type

jour

DOI

10.1109/TBCAS.2012.2202494

Filename

6243232