DocumentCode
2564047
Title
Cluster analysis of the p53 genetic regulatory network: topology and biology
Author
Hallinan, Jennifer S.
Author_Institution
Queensland Univ., St. Lucia, Qld., Australia
fYear
2004
fDate
7-8 Oct. 2004
Firstpage
1
Lastpage
8
Abstract
We describe a network module detection approach which combines a rapid and robust clustering algorithm with an objective measure of the coherence of the modules identified. The approach is applied to the network of genetic regulatory interactions surrounding the tumor suppressor gene p53. This algorithm identifies ten clusters in the p53 network, which are visually coherent and biologically plausible.
Keywords
cancer; genetics; medical computing; molecular biophysics; pattern clustering; proteins; tumours; gene p53; genetic regulatory interaction; network module detection; robust clustering algorithm; tumor; Bioinformatics; Cancer; Clustering algorithms; DNA; Databases; Genetics; Neoplasms; Network topology; Proteins; Robustness;
fLanguage
English
Publisher
ieee
Conference_Titel
Computational Intelligence in Bioinformatics and Computational Biology, 2004. CIBCB '04. Proceedings of the 2004 IEEE Symposium on
Print_ISBN
0-7803-8728-7
Type
conf
DOI
10.1109/CIBCB.2004.1393924
Filename
1393924
Link To Document