Title :
Cellular engineering: crash tests on human erythrocytes reveal hidden material properties of cellular proteins
Author :
Artmann, G.M. ; Kelemen, Ch ; Porst, D. ; Büldt, G. ; Chien, Shu
Author_Institution :
Dept. of Cell Biophys., Aachen Univ. of Appl. Sci., Julich, Germany
fDate :
29 Oct-1 Nov 1998
Abstract :
Human red blood cells (RBC) undergo a sudden change from blocking to passing through 1-μm-micropipettes at a transition temperature (Tc) of 36.4°C. For resealed RBC-ghosts this transition occurs at 28.3°C (Tg). These findings are attributed to elastomeric transitions of hemoglobin from being gel-like to a fluid and of membrane proteins such as spectrin
Keywords :
biomembranes; blood; cellular biophysics; haemorheology; proteins; viscoelasticity; 28.3 C; 36.4 C; aspiration; blocking to passing change; cell fragmentation; cellular engineering; cellular proteins; crash tests; critical temperature; elastomeric transitions; gel-like; hemoglobin; hidden material properties; human erythrocytes; human red blood cells; membrane proteins; membrane viscoelasticity; micropipettes; resealed RBC-ghosts; spectrin; viscosity; Biomedical engineering; Biomembranes; Cells (biology); Humans; Material properties; Proteins; Red blood cells; Temperature; Vehicle crash testing; Viscosity;
Conference_Titel :
Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE
Conference_Location :
Hong Kong
Print_ISBN :
0-7803-5164-9
DOI :
10.1109/IEMBS.1998.746073
