The protective effects of flavonoids from Astragalus complanatus on carbon tetrachloride induced hepatic fibrosis in mice

Author

Sun, Li-Bing ; Gu, Zhen-Lun ; Kwok, Ci-Yi ; Wang, Wei-Ping

fYear

2010

fDate

16-18 April 2010

Firstpage

374

Lastpage

377

Abstract

Aims: The aim of this study was to investigate the protective effects of FAC in hepatic fibrosis (HF) and the underlined mechanism. Methods: Using KM mice subjected to CCl₄-induced HF. At the end of the experiment, the tissues of liver were removed for histopathological examination and SOD, MDA, HYP assays. The expressions of PPARγ were detected by immunohistochemistry. Result: we found that administration of FAC significantly reduced the tissue malondialdehyde (MDA), hydroxypmline (HYP) contents, and also significantly increased superoxide dismutase (SOD) activities compared with model group. As shown in transmission electron microscope and pathological section. FAC treatment could protect hepatocyte in HF mice. Furthermore, it enhanced the expression of peroxisome proliferator -activated receptors γ ( PPARγ).

Keywords

biological tissues; carbon compounds; cellular biophysics; diseases; drugs; enzymes; injuries; liver; molecular biophysics; organic compounds; proteins; transmission electron microscopy; Astragalus Complanatus; FAC; HYP assay; KM mice; MDA assay; PPARγ; SOD assay; carbon tetrachloride; flavonoid; hepatic fibrosis; hepatocyte; hydroxypmline; immunohistochemistry; liver tissue; malondialdehyde; mice; peroxisome proliferator-activated receptors γ; superoxide dismutase; transmission electron microscope; Animals; Electrochemical machining; Immune system; Injuries; Liver; Mice; Organic materials; Petroleum; Protection; FAC; HF; MDA; PPARγ; SOD;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioinformatics and Biomedical Technology (ICBBT), 2010 International Conference on

Conference_Location

Chengdu

Print_ISBN

978-1-4244-6775-4

Type

conf

DOI

10.1109/ICBBT.2010.5478936

Filename

5478936