Effects of aldose reductase inhibitor in diabetic rats

Author

Nagai, Takahiro ; Sekizuka, E. ; Tsukada, Kosuke ; Shimizu, Tomoya ; Minamitani, Haruyuki ; Hokai, R. ; Oshio, Chikara

Author_Institution

Fac. of Sci. & Technol., Keio Univ., Yokohama, Japan

Volume

6

fYear

1998

fDate

29 Oct-1 Nov 1998

Firstpage

3098

Abstract

In microcirculation, RBC deformability is one of the most important factors. In this study, the effect of aldose reductase inhibitor (ARI) on RBC deformability in diabetic rats was investigated. Seven-week-old Wistar male rats were used as diabetic models. We injected streptozotocin (STZ) (55 mg/kg) intraperitoneally to make them diabetic. Then we administered ARI orally to the STZ rats. We classified them into STZ injected diabetic group (DM) and STZ and ARI treated diabetic group (ARI). Experiments were performed three weeks after STZ treatment. The RBC deformability was measured directly from microscope images of mesentery. From this experiment, it was found that ARI didn´t alter HbA1c, but improved the decreased RBC deformability in diabetes to the normal level

Keywords

biochemistry; blood; cellular biophysics; haemodynamics; RBC deformability; Wistar male rats; aldose reductase inhibitor effects; diabetic rats; enzyme activity reduction; erythrocytes; mesentery; microcirculation; microscope images; Biochemistry; Biomedical engineering; Cameras; Delta modulation; Diabetes; Image analysis; Inhibitors; Microscopy; Rats; Shape;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE

Conference_Location

Hong Kong

ISSN

1094-687X

Print_ISBN

0-7803-5164-9

Type

conf

DOI

10.1109/IEMBS.1998.746147

Filename

746147