Co-occurrence of core of binding sites for transcription factors in intronic region of Saccharomyces cerevisiae ribosomal protein genes

Eukaryotic transcriptional regulation is complex. Typically, it takes place by cooperative regulation. A number of studies have characterized this aspect in the upstream promoter sequences of Saccharomyces cerevisiae genes. In this paper, we performed an analysis of co-occurrence of motifs in introns. Here, we first conducted a Match™ program to detect single motifs for transcriptional factors. Second, pairing the motifs each other, we detected some co-occurring motifs that are statistically over-represented and distributed in a nonrandom fashion in introns of Saccharomyces cerevisiae. These results will be helpful to understand the mechanisms of transcriptional regulation for RP genes.