Title :
Model-free analysis of time-dependent single-molecule spectroscopy: Dynamics of biological macromolecules
Author :
Welsher, Kevin ; Yang, Haw
Author_Institution :
Dept. of Chem., Princeton Univ. Princeton, Princeton, NJ, USA
Abstract :
Rigorous and unbiased statistical analysis of single molecule data is now recognized as a crucial component to substantiate any discovery made through such experiments. This presentation summarizes many such tools, and ventures some future directions in the context of the dynamics of biological macromolecules.
Keywords :
biological techniques; biomolecular effects of radiation; fluorescence spectroscopy; macromolecules; statistical analysis; biological macromolecule dynamics; model free analysis; single molecule data; statistical analysis; time dependent single molecule spectroscopy; Chemicals; Fluorescence; Molecular biophysics; Proteins; Spectroscopy; Uncertainty; Fisher information; change point; maximum entropy; maximum information; protein dyamics; single-molecule FRET;
Conference_Titel :
Biomedical Imaging (ISBI), 2012 9th IEEE International Symposium on
Conference_Location :
Barcelona
Print_ISBN :
978-1-4577-1857-1
DOI :
10.1109/ISBI.2012.6235705
