Title :
The effects of 50 Hz magnetic fields and/or phorbol ester TPA on proto-oncogene expression
Author :
Wu, R.Y. ; Chiang, H. ; Fu, Y.D. ; Bao, J.L.
Author_Institution :
Microwave Inst., Zhejiang Med. Univ., Hangzhou, China
fDate :
29 Oct-1 Nov 1998
Abstract :
This study is designed to validate key experiments on induction of c-myc and c-fos gene expression by MF and or/TPA under well controlled conditions. No significant effects of ELF MF alone on the gene expression was observed, but one interesting finding is that 0.4 and 0.8 mT 50 Hz magnetic field can strengthen c-fos expression in Daudi cells induced by TPA. It is the first time that the result directly prove that MF exposure can cooperate TPA induction in c-fos gene transcription
Keywords :
biological effects of fields; biomagnetism; cellular effects of radiation; genetics; 0.4 mT; 0.8 mT; 50 Hz; Daudi cells; ELF fields; c-fos gene expression; c-myc gene expression; cancer link; cellular effects; gene transcription; magnetic fields effect; phorbol ester TPA effect; proto-oncogene expression; steady state transcript levels; Biomedical engineering; Coils; Electromagnetic fields; Gene expression; Geophysical measurement techniques; Ground penetrating radar; Humans; Laboratories; Magnetic field measurement; Magnetic shielding;
Conference_Titel :
Engineering in Medicine and Biology Society, 1998. Proceedings of the 20th Annual International Conference of the IEEE
Conference_Location :
Hong Kong
Print_ISBN :
0-7803-5164-9
DOI :
10.1109/IEMBS.1998.746199
