DocumentCode
2575151
Title
Remarks on structural identification, modularity, and retroactivity
Author
Sontag, Eduardo D.
Author_Institution
Dept. of Math., Rutgers Univ., Piscataway, NJ, USA
fYear
2010
fDate
15-17 Dec. 2010
Firstpage
3373
Lastpage
3378
Abstract
The “Modular Response Analysis” (MRA) reverse-engineering algorithm has been utilized in the systems biology literature in order to unravel the interactions between different “modules” in biochemical networks. We review the MRA technique, and discuss why its (mis-)application might lead to incorrect results due to impedance or load (“retroactivity”) effects, and present a computational criterion to discover stoichiometrically-dependent steady-state retroactivity.
Keywords
biochemistry; reverse engineering; biochemical network; modular response analysis reverse-engineering algorithm; stoichiometrically-dependent steady-state retroactivity; structural identification; structural modularity; structural retroactivity; systems biology; Chemicals; Differential equations; Interconnected systems; Jacobian matrices; Noise measurement; Proteins; Steady-state;
fLanguage
English
Publisher
ieee
Conference_Titel
Decision and Control (CDC), 2010 49th IEEE Conference on
Conference_Location
Atlanta, GA
ISSN
0743-1546
Print_ISBN
978-1-4244-7745-6
Type
conf
DOI
10.1109/CDC.2010.5717595
Filename
5717595
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