Title :
Remarks on structural identification, modularity, and retroactivity
Author :
Sontag, Eduardo D.
Author_Institution :
Dept. of Math., Rutgers Univ., Piscataway, NJ, USA
Abstract :
The “Modular Response Analysis” (MRA) reverse-engineering algorithm has been utilized in the systems biology literature in order to unravel the interactions between different “modules” in biochemical networks. We review the MRA technique, and discuss why its (mis-)application might lead to incorrect results due to impedance or load (“retroactivity”) effects, and present a computational criterion to discover stoichiometrically-dependent steady-state retroactivity.
Keywords :
biochemistry; reverse engineering; biochemical network; modular response analysis reverse-engineering algorithm; stoichiometrically-dependent steady-state retroactivity; structural identification; structural modularity; structural retroactivity; systems biology; Chemicals; Differential equations; Interconnected systems; Jacobian matrices; Noise measurement; Proteins; Steady-state;
Conference_Titel :
Decision and Control (CDC), 2010 49th IEEE Conference on
Conference_Location :
Atlanta, GA
Print_ISBN :
978-1-4244-7745-6
DOI :
10.1109/CDC.2010.5717595
