DocumentCode :
2575656
Title :
A comparison of high resolution ex vivo and interventional in vivo MR images and cellular response for thermal ablation treatment evaluation
Author :
Breen, M.S. ; Lazebnik, R.S. ; Lewin, J.S. ; Wilson, D.L.
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Volume :
2
fYear :
2002
fDate :
2002
Firstpage :
1190
Abstract :
We are treating patient tumors using radiofrequency (RF) ablation under interventional MRI (iMRI) guidance. We investigated the ability of high resolution ex vivo and interventional in vivo MR images to predict cellular response by comparing MR thermal lesion images to cellular damage as seen histologically. Our new methodology allows three dimensional (3D) registration that enables more accurate correlation than previous two dimensional (2D) methods. Using a low-field (0.2 T) open magnet iMRI system for electrode guidance, we applied RF current to the thigh muscles of 16 New Zealand White rabbits. After tissue dissection, a 1.5 T MRI system was used to obtain high resolution ex vivo images. To relate MR and histology images, we obtained intermediate pictures of thick tissue slices using a specially designed apparatus. Registration was done with a computer algorithm that matches tracks of needle fiducials placed near the site of interest. After registration, we determined the region inside the circular, hyper-intense rim in MR closely corresponds to the region of necrosis. This is good evidence that high resolution ex vivo and interventional in vivo MR images can be used to predict the cellular response for RF ablation treatments.
Keywords :
biomedical MRI; cellular biophysics; hyperthermia; image registration; medical image processing; radiofrequency heating; tumours; 0.2 T; 1.5 T; New Zealand White rabbits; RF ablation treatments; RF current; cellular response prediction; circular hyper-intense rim; computer algorithm; electrode guidance; high resolution ex vivo images; histology images; interventional magnetic resonance imaging; necrosis region; needle fiducials; tissue dissection; Electrodes; Image resolution; In vivo; Lesions; Magnetic resonance imaging; Medical treatment; Muscles; Neoplasms; Radio frequency; Thigh;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology, 2002. 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society EMBS/BMES Conference, 2002. Proceedings of the Second Joint
ISSN :
1094-687X
Print_ISBN :
0-7803-7612-9
Type :
conf
DOI :
10.1109/IEMBS.2002.1106342
Filename :
1106342
Link To Document :
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