DocumentCode
2576239
Title
The effect of retroactivity on the transfer function of a phosphorylation system
Author
Vecchio, Domitilla Del
Author_Institution
Dept. of Mech. Eng., Massachusetts Inst. of Technol., Cambridge, MA, USA
fYear
2010
fDate
15-17 Dec. 2010
Firstpage
2523
Lastpage
2528
Abstract
It was theoretically shown that impedance-like effects, called retroactivity, in biomolecular circuits can significantly impact the behavior of a system. In this paper, we quantify the effect of retroactivity on the transfer function of a phosphorylation system after linearization of its nonlinear model about a steady state. Our analysis shows that retroactivity shifts the poles of the transfer function toward the low frequency.
Keywords
biochemistry; molecular biophysics; physiological models; transfer functions; biomolecular circuits; impedance-like effects; phosphorylation system; retroactivity; transfer function; Bandwidth; Communication system signaling; Equations; Proteins; Steady-state; Transfer functions;
fLanguage
English
Publisher
ieee
Conference_Titel
Decision and Control (CDC), 2010 49th IEEE Conference on
Conference_Location
Atlanta, GA
ISSN
0743-1546
Print_ISBN
978-1-4244-7745-6
Type
conf
DOI
10.1109/CDC.2010.5717674
Filename
5717674
Link To Document