Title :
Control cell behavior on physical topographical surface
Author :
Su, Wen-Ta ; Chu, I-Ming ; Yang, Jung-Yen ; Huang, Chun-Kai
Author_Institution :
Dept. of Chem. Eng., Nat. Taipei Univ. of Technol., Hsinchu, Taiwan
Abstract :
Topographical cues, independent of biochemistry, generated by the PDMS substrate may have significant effects on cellular behavior. Mouse bone marrow stromal fibroblasts were examined on grooved substrata of equal groove and ridge width (30 /spl mu/m depth). It was found that the topographical surface had an effect in determining cell alignment and migration.
Keywords :
bone; cell motility; cellular biophysics; polymers; surface topography; 30 micron; PDMS substrate; biochemistry; cell alignment; cell migration; cell properties; control cell behavior; grooved substrata; mouse bone marrow stromal fibroblasts; physical topographical surface; polydimethylsiloxanes; Adhesives; Bones; Cells (biology); Chemical engineering; Chemical technology; Fibroblasts; Mice; Surface morphology; Surface texture; Surface topography;
Conference_Titel :
Microprocesses and Nanotechnology Conference, 2003. Digest of Papers. 2003 International
Conference_Location :
Tokyo, Japan
Print_ISBN :
4-89114-040-2
DOI :
10.1109/IMNC.2003.1268720
