Title :
InfoTech algorithms for optimizing BioTech practice on high-throughput differential detections among symptom/syndrome-related pathogens
Author_Institution :
Graduate Inst. of Biotechnol., Chinese Culture Univ., Taipei, Taiwan
Abstract :
The high-throughput differential detections among symptom/syndrome-related pathogens (SRP) are clinically important for subsequent diagnostic and therapeutic (theranostic) practice against epidemic diseases. For simple and complex microbial genomes of viruses and bacteria, instead of using a conventional primers set for costly polymerase chain reactions (PCR), the innovative design of minimum-set (MS) multiple-use SRP-primers may offer an optimal high-throughput solution for differentially detecting SRP target sequences on encompassed unique identification regions and repeat variation regions with respective probe-array hybridization (PAH) and genotype polymorphism (GTP). In summary, the efficient Info Tech algorithms of minimum-set multiple-use SRP-primers may indeed practically optimize the theranostic BioTech practice on high-throughput differential detections among symptom/syndrome-related pathogens with either simple or complex microbial genomes.
Keywords :
biology computing; biotechnology; diseases; genetics; microorganisms; Info Tech algorithms; InfoTech algorithms; SRP target sequences; bacteria; diagnostic practice; differential detections; epidemic diseases; genotype polymorphism; microbial genomes; minimum-set multiple-use SRP primers; polymerase chain reactions; probe-array hybridization; symptom/syndrome-related pathogens; theranostic BioTech practice; therapeutic practice; viruses; Annealing; Bioinformatics; Clustering algorithms; DNA; Genomics; Laboratories; Microorganisms; Pathogens; Sequences; Viruses (medical);
Conference_Titel :
Emerging Information Technology Conference, 2005.
Print_ISBN :
0-7803-9328-7
DOI :
10.1109/EITC.2005.1544379