Digital closed-loop control of plasma glycemia

This paper investigates the problem of plasma glucose regulation by means of intra-venous insulin administration. A model-based approach is followed, according to a discrete-time framework, since the available standard technology provides sampled glucose measurements and piece-wise constant insulin delivery devices. The digital control scheme is designed on the basis of an approximated sampled model, whose continuous-time original version is available in the recent literature, and has been shown to very well resemble real data on healthy subjects as well as on diabetic patients (both type 1 and type 2 Diabetes Mellitus). In silico simulations show the high performance of the proposed digital control law.