Title :
Simulation of the therapeutic region during HIFU therapy
Author :
Xiaorui, Chen ; Xiaojing, Zhang ; Shaolin, Wang ; Xiqi, Jian
Author_Institution :
Sch. of Biomed. Eng., Tianjin Med. Univ., Tianjin, China
Abstract :
Prediction of the size, shape, and variation of the therapeutic region (TR) induced by HIFU has a great significance to HIFU treatment planning. In this study, the approximation of Westervelt formula for the nonlinear propagation of ultrasound and Pennes bio-heat transfer equation have been used along with the Finite Difference Time Domain (FDTD) method to calculate the temperature field. Then the therapeutic region based on the temperature distribution was analyzed. It was found that an increase of the exposure time and the TR temperature resulted in the appearance of the influence of tissue acoustic properties. It was also found that during the process of obtaining the same lesion size, the average input intensity and the exposure time express a certain relationship.
Keywords :
biological tissues; biomedical ultrasonics; finite difference time-domain analysis; heat transfer; hyperthermia; radiation therapy; temperature distribution; transfer functions; ultrasonic focusing; ultrasonic propagation; ultrasonic therapy; HIFU therapy; Pennes bio-heat transfer equation; Westervelt formula; average input intensity; finite difference time domain method; high intensity focused ultrasound; lesion size; nonlinear ultrasound propagation; temperature distribution; temperature field; tissue acoustic properties; Acoustics; Mathematical model; Numerical models; Temperature distribution; Temperature measurement; Ultrasonic imaging; FDTD; HIFU; acoustic properties; therapeutic region;
Conference_Titel :
Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-9351-7
DOI :
10.1109/BMEI.2011.6098400
