Computer simulation of a mathematical model of HAART therapy for HIV-1 AIDS

Author

Nani, Frank ; Jin, Mingxian

Author_Institution

Dept. of Math. & Comput. Sci., Fayetteville State Univ., Fayetteville, NC, USA

Volume

4

fYear

2011

fDate

15-17 Oct. 2011

Firstpage

1829

Lastpage

1833

Abstract

A clinically plausible mathematical model is constructed to describe the patho-physiological dynamics of HIV-1 induced AIDS during HAART therapy. The model equations incorporate physiological interactions between non-infected helper T cells, HIV-1 infected helper T cells, HIV-1 virions in the blood plasma, HIV-1 specific cytotoxic T cells and drug molecules of the HAART protocol. Investigative computer simulations are performed to elucidate some therapeutic scenarios such as viral annihilation and efficacious HAART therapy. In particular, some mathematical criteria are derived for therapeutic outcomes such as viral persistence and viral annihilation.

Keywords

blood; cellular biophysics; diseases; drugs; medical computing; patient treatment; physiological models; toxicology; HAART therapy; HIV-1 AIDS; HIV-1 infected helper T cells; HIV-1 specific cytotoxic T cells; HIV-1 virions; blood plasma; drug molecules; mathematical model; noninfected helper T cells; pathophysiological dynamics; viral annihilation; viral persistence; Cells (biology); Computational modeling; Computer simulation; Drugs; Mathematical model; Protocols; AIDS cure criteria; HAART therapy; HIV-1 dynamics; computer simulations; mathematical modeling;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Engineering and Informatics (BMEI), 2011 4th International Conference on

Conference_Location

Shanghai

Print_ISBN

978-1-4244-9351-7

Type

conf

DOI

10.1109/BMEI.2011.6098678

Filename

6098678