Cytochrome c release caused by Pulsed Electric Fields (PEFs) with different time durations

Author

Wu, Hao ; Wu, Minghe ; Zou, Heng

Author_Institution

Sch. of Phys. Electron., Univ. of Electron. Sci. & Technol. of China (UESTC), Chengdu, China

fYear

2012

fDate

19-20 April 2012

Firstpage

1

Lastpage

3

Abstract

Multilayer Dielectric Sphere Model (MDSM) is used for analyzing responses of cells to Pulsed Electric Fields (PEFs), and cytochrome c release is significant effect of PEFs when mitochondrial substructures are taken into account. Numerical results of MDSM model explain and verify the reported experimental results on Intracellular Electro-manipulation (IEM). It is proposed that two-step process of cytochrome c release can be implemented by bioelectric impulse effect on mitochondria.

Keywords

biological effects of fields; cellular biophysics; bioelectric impulse effect; cytochrome c release; intracellular electromanipulation; mitochondrial substructures; multilayer dielectric sphere model; pulsed electric fields; Biological system modeling; Biomembranes; Conductivity; Dielectrics; Electric fields; Nonhomogeneous media; Plasmas; Cytochrome c Release; Intracellular Electro-manipulation; Multilayer Dielectric Sphere Model; Pulsed Electric Field;

fLanguage

English

Publisher

ieee

Conference_Titel

Microwave and Millimeter Wave Circuits and System Technology (MMWCST), 2012 International Workshop on

Conference_Location

Chengdu

Print_ISBN

978-1-4673-1893-8

Type

conf

DOI

10.1109/MMWCST.2012.6238126

Filename

6238126