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The following topics are dealt with: signal processing and statistical approaches for functional genomics; computational biology; computational genomics and epigenomics; personal sequencing; discovery of molecular signatures and biomarkers; gene and protein sequence analysis; analysis of microarray and mass spectrometry data; denoising and compression of genomic data; regulatory network modeling, simulation, and inference; pathways and regulatory genomic networks; dynamic modeling of gene networks; genomic data mining and pattern recognition; cellular modeling and metabolism; meta-analysis of high throughput molecular studies; integrated analysis of diverse high-throughput data; molecular dynamics and simulation; novel assembly and alignment methods; reverse engineering assessments and methods; genome comparisons and summarization; molecular structure and interaction; modeling in synthetic biology; and molecular evolution and phylogeny.