DocumentCode :
2600815
Title :
Network propagation models for gene selection
Author :
Zhang, Wei ; Hwang, Baryun ; Wu, Baolin ; Kuang, Rui
Author_Institution :
Dept. of Comput. Sci. & Eng., Univ. of Minnesota - Twin Cities, Minneapolis, MN, USA
fYear :
2010
fDate :
10-12 Nov. 2010
Firstpage :
1
Lastpage :
4
Abstract :
In this paper, we explore several network propagation methods for gene selection from microarray gene expression datasets. The network propagation methods capture gene co-expression and differential expression with unified machine learning frameworks. Large scale experiments on five breast cancer datasets validated that the network propagation methods are capable of selecting genes that are more biologically interpretable and more consistent across multiple datasets, compared with the existing approaches.
Keywords :
bioinformatics; cancer; genetics; learning (artificial intelligence); molecular biophysics; breast cancer datasets; differential expression; gene co-expression; gene selection; machine learning; microarray gene expression dataset; network propagation model; Bioinformatics; Biomarkers; Bipartite graph; Breast cancer; Correlation; Gene expression; Biomarkers; Breast Cancer Metastasis; Gene Expression; Network Propagation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Genomic Signal Processing and Statistics (GENSIPS), 2010 IEEE International Workshop on
Conference_Location :
Cold Spring Harbor, NY
ISSN :
2150-3001
Print_ISBN :
978-1-61284-791-7
Type :
conf
DOI :
10.1109/GENSIPS.2010.5719689
Filename :
5719689
Link To Document :
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