Title :
Evaporative pumping of liquid in nanochannel for electrical measurement of a single biomolecule in nanofluidic format
Author :
Lennon, Erwan ; Yamamoto, Takatoki ; Lee, Sang Wook ; Fujii, Teruo
Author_Institution :
Fujii Lab., Univ. of Tokyo, Tokyo
Abstract :
We present a solution to obtain planar micro-electrodes self-aligned around a nanochannel drilled using focused ion beam (FIB) machining . The inter-electrode spacing is exactly that of the width of the nanochannel (100 to 600 nm ). The system is sealed with a PDMS (polydimethylsiloxane) thin foil that includes microfluidic channels. We are aiming at manipulation and characterization of single biomolecules by taking advantages of electrical measurements at nanoscale. As a result of pumping in the nanochannel, it has been observed that high-speed motion of DNA molecules due to evaporation-coupled capillary action. Electrical detection and measurements are currently being conducted.
Keywords :
biomedical electrodes; focused ion beam technology; microelectrodes; microfluidics; molecular biophysics; nanobiotechnology; DNA molecules; PDMS; biomolecule; electrical measurement; evaporation-coupled capillary; evaporative pumping; focused ion beam machining; interelectrode spacing; nanochannel; nanofluidics; planar microelectrodes; polydimethylsiloxane; Electric variables measurement; Molecular biophysics; Nanotechnology; DNA; nano-gap electrode; nanochannel; nanofluidic device; single-molecular detection;
Conference_Titel :
Nanotechnology, 2007. IEEE-NANO 2007. 7th IEEE Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-0607-4
Electronic_ISBN :
978-1-4244-0608-1
DOI :
10.1109/NANO.2007.4601254
