Design and feasibility study of Gamma-Cube — a high resolution and high sensitivity SPECT system for in vivo mouse brain studies

Author

Fu, G. ; Meng, L.J. ; Chen, C.T.

Author_Institution

Department of Nuclear, Plasma and Radiological Engineering, the University of Illinois at Urbana Champaign, USA

fYear

2008

fDate

19-25 Oct. 2008

Firstpage

3855

Lastpage

3860

Abstract

In this paper, we report the design and feasibility study of a high resolution and high sensitivity SPECT (Gamma-Cube) system for mouse brain imaging. The system consists of six high resolution gamma ray detectors, arranged in cubic geometry, and a truncated spherical aperture with multiple pinholes, which offers a relatively uniform 4π angular coverage around the object. The proposed Gamma-Cube system is based on the so-called energy-resolved photon-counting (ERPC) detector that consists of multiple pixilated CdTe detectors bump-bonded to ERPC readout ASICs that are 1.1×2.2cm in size with a pixel pitch of 350μm×350μm. In this study, we used Monte Carlo simulation to optimize system geometry and multiple-pinhole patterns for detection of a tiny amount of radioactivity in mouse brain.

Keywords

Brain; Energy resolution; Gamma ray detection; Gamma ray detectors; Geometry; High-resolution imaging; Image resolution; In vivo; Mice; Optical imaging; ERPC; Gamma-Cube; spherical aperture;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium Conference Record, 2008. NSS '08. IEEE

Conference_Location

Dresden, Germany

ISSN

1095-7863

Print_ISBN

978-1-4244-2714-7

Electronic_ISBN

1095-7863

Type

conf

DOI

10.1109/NSSMIC.2008.4774122

Filename

4774122