Discovery of Novel Relationship among Single Nucleotide Polymorphisms, Exon Skipping Events, and Tumors

Author

Hsu, Fang Rong ; Lo, Wen Chun

Author_Institution

Dept. of Inf. Eng. & Comput. Sci., Feng Chia Univ., Taichung, Taiwan

fYear

2009

fDate

17-20 April 2009

Firstpage

517

Lastpage

520

Abstract

Expressed sequence tags (ESTs) are single-pass sequence reads from cDNA clones. ESTs usually represent genes expressed in a particular tissue. Single nucleotide polymorphism (SNP) is a very important resource for protein structure and function. It may make a contribution to understand a complex disease, such as tumor. Through analysis of large scale human ESTs, we try to find relationship among SNPs, exon skipping events, and tumors. We found 784 human SNPs are related to exon skipping (ES) events. A total of 395 tumor-specific exon skipping events were found. Our test revealed 38,776 SNPs having an association with tumor.

Keywords

DNA; bioinformatics; genomics; molecular biophysics; molecular configurations; proteins; tumours; cDNA clones; exon skipping events; expressed sequence tags; large scale human EST; protein function; protein structure; single nucleotide polymorphisms; single pass sequence reads; tumors; Anatomy; Avatars; Bioinformatics; Cancer; Databases; Diseases; Genomics; Humans; Libraries; Neoplasms; Alternative Splicing; Exon Skipping; SNP; Tumor;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer Science and Information Technology - Spring Conference, 2009. IACSITSC '09. International Association of

Conference_Location

Singapore

Print_ISBN

978-0-7695-3653-8

Type

conf

DOI

10.1109/IACSIT-SC.2009.111

Filename

5169406