Generation of hybrid SPECT bone scans and reconstruction using CT-derived anatomical priors

Anatomical priors derived from CT scans offer the promise of improved image quality in SPECT reconstruction. We describe reconstruction of clinical SPECT/CT bone scans of the spine using anatomical priors to enhance SPECT. We also generate hybrid images: lesion-absent backgrounds from a clinical scan with a synthetic lesion generated by Monte Carlo simulation. These hybrids can be used to assess the change in image quality due to anatomical priors.