DocumentCode :
2616714
Title :
Laser Doppler flowmetry in healthy rats: impact of isoflurane anesthetic on signal complexity
Author :
Humeau, Anne ; Haussy, Bernard ; Fizanne, Lionel ; Roux, Jérôme ; Asfar, Pierre ; Calés, Paul ; Rousseau, David ; Chapeau-Blondeau, François
fYear :
2008
fDate :
25-27 June 2008
Firstpage :
1330
Lastpage :
1334
Abstract :
Laser Doppler flowmetry (LDF) technique is an optical tool used in clinical investigations to monitor microvascular blood flow. Recent preliminary works have shown that LDF signals recorded in young healthy human subjects are weakly multifractal. Such an information is important as it could lead to a better knowledge of the underlying optical processes giving rise to the signals. In the present work, our goal is to analyze the behavior of LDF signals in anesthesia conditions. For this purpose, we herein study the possible modifications brought by isoflurane, an anesthetic commonly used in clinical practice, on the complexity of LDF signals. In order to conduct our work, twenty LDF signals from anesthetized healthy rats are processed. Anesthesia is performed by using doses of isoflurane varying between 1.5% and 3%, which leads to very light and very deep anesthesia, respectively. The signal processing approach is carried out with two different methods, a parametric generalized quadratic variation based estimation method and a Hurst rescaled range analysis. The results show that extreme doses of isoflurane lead to no distinguishable modification on the characterization of LDF signals based on the two above approaches. These findings infer that, if isoflurane changes the microvascular tissue optical properties, these modifications have no influence on LDF signals complexity measured by the two signal processing approaches used herein.
Keywords :
Doppler effect; blood flow measurement; flowmeters; laser applications in medicine; medical signal processing; Hurst rescaled range analysis; anesthesia; clinical investigations; healthy rats; isoflurane anesthetic; laser Doppler flowmetry; microvascular blood flow monitoring; microvascular tissue optical properties; parametric generalized quadratic variation; signal complexity; signal processing approach; Anesthesia; Anesthetic drugs; Blood flow; Humans; Monitoring; Optical recording; Optical signal processing; Rats; Signal analysis; Signal processing;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Control and Automation, 2008 16th Mediterranean Conference on
Conference_Location :
Ajaccio
Print_ISBN :
978-1-4244-2504-4
Electronic_ISBN :
978-1-4244-2505-1
Type :
conf
DOI :
10.1109/MED.2008.4602017
Filename :
4602017
Link To Document :
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