Towards an optical biopsy by elastic light scattering

Author

Andraud, C. ; Bordier, C. ; Lafait, J.

Author_Institution

Univ. Pierre et Marie Curie-Paris 6, Paris

fYear

2008

fDate

25-27 June 2008

Firstpage

1364

Lastpage

1368

Abstract

Our aim is to develop an optical biopsy method for an early detection of cancer in hollow organs. A model accounting for light scattering in a multistratified, heterogeneous and scattering system, with a geometry close to biological tissues is presented. It is based on the resolution of the Vector Radiative Transfer Equation by the discrete ordinate method. It calculates the spatial distribution and the spectral variations of the scattered light according to various states of polarization. It has been validated on phantoms samples. A simulation of the cancerization process inside an epithelium, by using this model, shows that it should be possible to distinguish a healthy tissue from a dysplasic one.

Keywords

bio-optics; biological organs; biomedical measurement; cancer; light polarisation; light scattering; patient diagnosis; phantoms; tumours; biological tissue; cancer; discrete ordinate method; elastic light scattering; light polarization; optical biopsy method; patient diagnosis; phantom; vector radiative transfer equation; Biological system modeling; Biological tissues; Biomedical optical imaging; Biopsy; Cancer detection; Geometrical optics; Light scattering; Optical scattering; Solid modeling; Spatial resolution;

fLanguage

English

Publisher

ieee

Conference_Titel

Control and Automation, 2008 16th Mediterranean Conference on

Conference_Location

Ajaccio

Print_ISBN

978-1-4244-2504-4

Electronic_ISBN

978-1-4244-2505-1

Type

conf

DOI

10.1109/MED.2008.4602265

Filename

4602265