Title :
Cellular mechanics and DNA mechanics via optical manipulation
Author_Institution :
National Yang-Ming Univ., Taipei, Taiwan
Abstract :
Optical trapping and manipulation of micro-particles have been investigated for a wide variety of applications since the first experimental observation reported by Ashkin in 1970. This subject has received increasing attention in recent years due to their unique potential applications in biological, biomedical, and nanosciences and technologies. In this paper, I briefly review two recent important developments of optical trapping and manipulation, namely photonics force microscopy (PFM) based on single-beam gradient-force trap (also know as optical tweezers) and optical stretcher (or optical trap-and-stretch) based on a counter-propagating dual-beam configuration. Potential applications of these techniques to DNA mechanics and cellular mechanics will be discussed, and some preliminary experimental data will be presented.
Keywords :
DNA; bio-optics; biomechanics; cellular biophysics; molecular biophysics; optical microscopy; radiation pressure; reviews; DNA mechanics; biological technology; biomedical technology; cellular mechanics; counter-propagating dual-beam configuration; microparticles; nanosciences; optical manipulation; optical stretcher; optical trap-and-stretch; optical trapping; optical tweezers; photonics force microscopy; review; single-beam gradient-force trap; Atom optics; Biomedical optical imaging; Charge carrier processes; DNA; High speed optical techniques; Integrated optics; Optical microscopy; Optical refraction; Power lasers; Tracking;
Conference_Titel :
Lasers and Electro-Optics Society, 2005. LEOS 2005. The 18th Annual Meeting of the IEEE
Print_ISBN :
0-7803-9217-5
DOI :
10.1109/LEOS.2005.1547896
