Title :
Automatic quantification of microtubule dynamics
Author :
Hadjidemetriou, Stathis ; Duncan, James S. ; Toomre, Derek ; Tuck, David
Author_Institution :
Dept. of Electr. Eng. & Diagnostic Radiol., Yale Univ., New Haven, CT, USA
Abstract :
The dynamics of the microtubule assembly are very significant both for cell function and structure. Abnormal function of the assembly is involved in neurodegenerative diseases and cancer. Currently, microtubule dynamics are typically analyzed manually, which is time consuming and limiting. We present an algorithm that quantifies the microtubule dynamics automatically. The quantification becomes simpler, easier, and more extensive. We examine the sensitivity of the algorithm using phantom as well as real data.
Keywords :
biomedical optical imaging; cancer; cellular biophysics; fluorescence; molecular biophysics; neurophysiology; phantoms; cancer; cell function; cell structure; epifluorescent confocal microscopy; microtubule dynamics; neurodegenerative diseases; phantom; Alzheimer´s disease; Assembly; Cancer; Drugs; Image edge detection; Imaging phantoms; Microscopy; Motion estimation; Tracking; Vehicle dynamics;
Conference_Titel :
Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on
Print_ISBN :
0-7803-8388-5
DOI :
10.1109/ISBI.2004.1398623