Title :
Influence of oxygen microenvironment on microfluidic glucose sensor performance
Author :
Kim, Chang-Soo ; Park, Jongwon
Author_Institution :
Dept. of Electr. & Comput. Eng., Missouri Univ., Rolla, MO, USA
Abstract :
We propose a novel method to overcome significant problems of baseline drift and sensitivity degradation in amperometric biosensors based on oxidase enzyme reactions. A novel glucose microsensor with a built-in electrochemical oxygen manipulation microsystem is introduced to demonstrate three novel functionalities; one-point in situ self-calibration (zero-point), broadening of dynamic range and increase in sensitivity. The influence of electrochemically generated oxygen microenvironment on the sensor output within a fluidic structure is investigated.
Keywords :
amperometric sensors; biosensors; electrolysis; enzymes; microfluidics; microsensors; amperometric biosensors; baseline drift; electrochemical oxygen manipulation microsystem; glucose microsensor; microfluidic glucose sensor; oxidase enzyme reactions; oxygen microenvironment; Biochemistry; Biosensors; Calibration; Electrochemical processes; Electrodes; Hydrogen; Microfluidics; Microsensors; Sugar; Thin film sensors; bubble; electrolysis; hydrogen; oxygen;
Conference_Titel :
Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on
Print_ISBN :
0-7803-8711-2
DOI :
10.1109/MMB.2005.1548374
