Title :
Three-dimensionally patterned cardiomyocytes with high activity for powering bio-hybrid microdevices
Author :
Kim, Deok-Ho ; Park, Jungryul ; Suh, Kahp Y. ; Kim, Pilnam ; Choi, Seung Kyu ; Lee, Sang Ho ; Kim, Byungkyu
Author_Institution :
Microsyst. Res. Center, Korea Inst. of Sci. & Technol., Seoul, South Korea
Abstract :
We have demonstrated a simple method for patterning cardiac muscle cells with high activity on a micron scale for powering bio-hybrid microdevices. The morphology and mobility of patterned cardiac muscle cells within micro wells were analyzed with different topographical heights of the barrier. We found that three-dimensionally grown cardiac cells mediated by a higher physical barrier generated higher contraction force with faster beating frequency than those of cells attached to the collagen-coated surface on the culture dish (control), suggesting that control over cell growth and shape would be critical for potential engineered cellular motors. Thus, the micro patterned cardiac muscle cells presented here would provide a primary platform for building up 3-D bioactuated microdevices including an engineered cell motor.
Keywords :
biological techniques; cardiology; cellular biophysics; lithography; micromechanical devices; muscle; bio-hybrid microdevices; cell motor; micro wells; patterned cardiac muscle cell mobility; patterned cardiac muscle cell morphology; three-dimensionally patterned cardiomyocytes; Cardiology; Force control; Microstructure; Muscles; Plasma properties; Power engineering and energy; Shape control; Surface morphology; Surface topography; Surface treatment; Bioactuator; bio-hybrid microdevice; capillary lithography; cardiac muscles; cell patterning;
Conference_Titel :
Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on
Print_ISBN :
0-7803-8711-2
DOI :
10.1109/MMB.2005.1548436